P32: POST-OPERATIVE RELATIVE PARATHORMONE DECLINE (ΔPTH%) AND ABSOLUTE PARATHORMONE DECLINE (ΔPTH) LEVELS ARE BETTER MARKERS OF SYMPTOMATIC HYPOCALCEMIA FOLLOWING TOTAL THYROIDECTOMY THAN POST-OPERATIVE PTH ALONE
نویسندگان
چکیده
Abstract Introduction Hypocalcemia is a frequent complication following thyroidectomy which can delay discharge and increase overall treatment expenditure. We aimed to assess the predictive value of absolute relative intact Parathormone(iPTH) decline levels as reliable markers post-operative hypocalcemia. Method This prospective study included 95 consecutive patients at our tertiary care centre. Patients underwent either Total Thyroidectomy(TT), TT+Central Neck Dissection(CND) or TT+CND+Modified Radical Dissection(MRND). iPTH were measured four hours after surgery morning surgery(POD 1). iPTH, decline(ΔPTH) decline(ΔPTH%) calculated correlated with Comparisons between groups by chi-square test, Fischer's exact test Mann-Whitney U test. Result Of patients, 59 had malignant disease, while 36 benign histopathology. TT was performed in 69 TT+CCLND 7, TT+CCLND+MRND 19. 32.6% patients(n=31) biochemical hypocalcemia 20%(n=19) symptomatic The mean calcium cohort on Post-operative day(POD)-1 8.3±0.66(range=6.5-9.9) POD-3 8.4±0.69(range=6.3–10.7). Median PTH, 4 24pg/ml(IQR–23.4;range 2.5–85.5), POD-1 28pg/ml(IQR–27.6;range=2-79). ΔPTH(U=206;p<0.001) & ΔPTH% (U=127;p<0.001) significantly higher A 20%(sensitivity=84%;specificity=91%) ΔPTH 3.75 pg/ml(sensitivity = 74%; specificity=87%) good predictors Conclusion are thyroid have potential facilitate safe early for undergoing TT. 20% fall PTH level(ΔPTH%) be useful marker Take-home message better than single alone.
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2021
ISSN: ['1365-2168', '0007-1323']
DOI: https://doi.org/10.1093/bjs/znab117.117